What is Flexiseq?
FLEXISEQ (sometimes referred to as TDT 064 in scientific literature) is an aqueous gel that contains hydrophilic, nanoscale lipid vesicles with a phospholipid bilayer (Sequessome vesicles). FLEXISEQ gel is technically a medical device due to it having a physical mode of action and contains no active drugs.
In this article, we talk about Flexiseq in more detail, answering some of the more common questions about this gel and whether or not it is the right choice for you.
Is Flexiseq an anti-inflammatory?
FlexiSEQ is drug free because it contains Sequessome vesicles, and therefore Flexiseq has none of the side effects associated with other OA gels that actually contain Non-Steroidal Anti–inflammatory Drugs (NSAIDs).
Flexiseq is an anti-inflammatory due to how this gel works when it is applied to the skin.
What is the active ingredient in Flexiseq?
Flexiseq is made from an aqueous gel containing hydrophilic, nanoscale lipid vesicles made from phospholipid bilayer (Sequessome vesicles). These are designed to pass through your skin into your joint. A potential innovative aspect is that it is described as having a novel, physical mode of action and contains no active drug.
How long does a tube of Flexiseq last?
Flexiseq claims that with the recommended application of twice a day, a 125 g tube of Flexiseq will last for 28 days on average, but this will vary based on the number and size of joints being treated by Flexiseq.
With average use, a tube of Flexiseq should last you around 4 weeks.
Is Flexiseq gel any good?
FLEXISEQ had similar effectiveness on pain, function and stiffness as a gel containing ketoprofen and celecoxib tablets, and it was more effective than a placebo tablet. Pain reduction was between 38–41% for all the treatments, compared to 29% reduction in those taking inactive tablets.
So, what exactly is Flexiseq?
FLEXISEQ is an aqueous gel containing hydrophilic nanoscale lipid vesicles, phospholipids bilayers and sequessome vesicles. It consists of the gel, which consists of the phospholIPID double layer and the sequessomes. Flexiseq is drug-free as it contains only the sequential vesicles and has none of the side effects associated with other gels containing non-steroidal anti-inflammatory drugs (NSAIDs). It is a medical device as it has a physical mode of action and does not contain active drugs.
The potentially innovative aspect is described as a novel physical mode of action containing a biologically active drug. The gel is designed to pass through the skin and into the joints.
FLEXISEQ states that the recommended application per day is 1.25g per tube and lasts on average up to 28 days, although this varies depending on the number and size of the joints treated. On average, the application of a tube flexiseq takes about 4 weeks.
FLEXISEQ has a similar effect on pain, function and stiffness as ketoprofen or celecoxib-containing gels, but is more effective than placebo tablets. Pain reduction ranged from 38% to 41% after treatment, compared to 29% when taking inactive tablets.